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. 2016 Jun 17;48(6):e240. doi: 10.1038/emm.2016.39

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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PLC-β3 is required for blood vessel integrity and tumor angiogenesis. (a) P6 stage of retinas were isolated from WT and PLC-β3 knockout mice and stained with IB4 (blue). Images were captured on microscope at × 10 (upper) and × 20 (lower). White arrowheads indicate abnormal blood vessels. Data are representative images (n=6 for each group). Scale bar, 100 μm. (b) Retinas from WT and PLC-β3 knockout mice were visualized on bright-field microscope at × 5 magnification. Data are representative images (n=6 for each group). Scale bar, 500 μm. (c) B16-BL6 melanoma cells were injected into WT and PLC-β3 knockout mice. After 2 weeks, tumor weights were measured. Data are means±s.e.m. (n=3 for each group). Asterisks indicate statistical significance (P<0.05). (d) Tumor masses isolated from above were stained with SM22α (green). Images were captured on confocal microscope at × 20 magnification. Scale bar, 100 μm.