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. 2016 Jun 24;48(6):e241. doi: 10.1038/emm.2016.47

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Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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The effect of SOCS1 on IL-1β-induced C/EBPβ expression. (a) IL-1β-induced C/EBPβ mRNA expression was significantly increased in SW1353 cells with knockdown of the SOCS1 gene (gray bars), and decreased in the SOCS1-overexpressing SW1353 cells after 8 h (black bars; n=3). (b) A representative immunoblot showing that IL-1β-induced expression of the C/EBPβ protein was lower in SOCS1-overexpressing SW1353 cells than in other cells (lane 1, empty vector; lane 2, SOCS1 vector; lane 3, scramble shRNA; lane 4, SOCS1 shRNA). (c) SOCS1 decreased the levels of IL-1β-induced C/EBPβ transcript and protein expression in human articular chondrocytes (HACs) electrotransfected with the SOCS1 vector (n=5). (d) C/EBPβ knockdown or overexpression did not affect the levels of SOCS1 mRNA upon IL-1β stimulation (n=3). Data are expressed as the mean±s.e.m. *P<0.05.