Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The effect of SOCS1 on CREB phosphorylation. (a) IL-1β stimulation led to significantly increased amounts of phospho-CREB protein at 15–60 min post stimulation in SOCS1-knockdown SW1353 cells (gray bars) compared with control shRNA-transfected cells (white bars). (b) In contrast, phospho-CREB levels were significantly lower at 5–15 min in SOCS1-overexpressing SW1353 cells (black bars). The densitometry data were normalized to β-actin and expressed as the means±s.e.m. (n=3). *P<0.05.
