Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 24;48(6):e241. doi: 10.1038/emm.2016.47

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 KSBMB.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

The involvement of a p38 MAPK on CREB phosphorylation and the interaction between HIF-2α and SOCS1. (a) Pretreatment with SB202190 suppressed IL-1β (10 ng ml⁻¹) induced expression of phospho-CREB in a dose-dependent manner. In addition, in SOCS1-overexpressing SW1353 cells, IL-1β-induced CREB phosphorylation was further increased by adding anisomycin (ANS) as a p38 kinase inhibitor. (b) Under normoxic conditions, IL-1β induced C/EBPβ expression, but not HIF-2α expression. Hypoxia-induced HIF-2α expression was unchanged by SOCS1. The densitometry data were normalized to β-actin and expressed as the means±s.e.m. (n=3).