Figure 4.

Simulation of the time-course of T₂ and ADC using the CED model. Panels (a) and (b) show the early time dependence of T₂ (a) and ADC (b) respectively, demonstrating different behaviour for different oedema timescales (given by δ). Panels (c) and (d) shows T₂ (c) and ADC (d) kinetics over a longer timescale, for a fixed value of δ = 2 min but different values of β (the lesion growth coefficient), which is the main determinant of T₂ and ADC kinetics after 30 min. Panel (e) shows the lesion volume kinetics for different β values; panel (f) shows the heterogeneity of T₂ within a simulated circular lesion 2 h after onset at β = 60 min.