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. 2015 Nov 11;36(7):1257–1270. doi: 10.1177/0271678X15616400

Figure 6.

Figure 6.

VCI mice have an increase in reactive changes in the CA1 region of the hippocampus, which are exacerbated by HF diet. Brains were collected 3.5 months after VCI or sham surgery and labeled for GFAP and Iba-1. (a) VCI mice showed increased the percent Iba-1 labeling in the right hemisphere CA1 region of the hippocampus compared to the left hemisphere CA1, regardless of diet (*p < 0.05 vs. sham mice). (b) HF VCI mice showed increased Iba-1 labeling in the right hemisphere CA1 compared to LF VCI mice (**p < 0.01 vs. LF sham). (c) VCI mice showed trend toward increased the percent GFAP labeling in the right hemisphere CA1 compared to the left hemisphere CA1, regardless of diet (p = 0.06 vs. sham mice). (d) VCI mice showed increased GFAP labeling in the right hemisphere CA1 compared to sham mice (*p < 0.05 vs. Sham). N = 6–7 per group for all measures. (e) Representative images of Iba-1 and GFAP labeling in the CA1 region of the right (ischemic; top images) and left (non-ischemic; bottom images) hemisphere of HF VCI mice. Scale bar = 100 µm. Scale bar = 100 µm.