Representative maps of estimated brain parameters obtained with a high-resolution GESSE (gradient-echo sampling of spin echo)88 pulse sequence. The top leftmost image is a high-resolution anatomic image. The rest of the maps are deoxygenated blood fraction (%), OEF (%), R2 of brain tissue (R2t, s−1), interstitial fluid and cerebrospinal fluid (ISF/CSF) volume fraction, ISF/CSF frequency shift (Hz), R2′ of brain tissue (s−1), and brain deoxyhemoglobin concentration (μM). Reproduced from He et al.,52 with permission.