Table 1.
In vitro activity profile of 56 FDA compounds (including 2 reference compounds) against A. ceylanicum and T. muris adult and larval stages
| Compound | Drug effect (%) | |||||
|---|---|---|---|---|---|---|
| A. ceylanicum L3 200 μM (72 h) | H. polygyrus L3 200 μM (72 h) | T. muris L1 100 μM (24 h) | A. ceylanicum adult 50 μM (72 h) | H. polyygrus adult 50 μM (72 h) | T. muris adult 50 μM (72 h) | |
| Levamisole | 100 | 100 | 100 | 0 | 56 | 100 |
| Ivermectin | 100 | 93 | 0 | 100 | 41 | 0 |
| Abamectin | 100 | ND, anthelmintic | ||||
| Amitriptyline HCl | 91 | ND, toxic | ||||
| Apomorphine HCl | 72 | ND, toxic | ||||
| Bifonazole | 67 | ND, topical application | ||||
| Bitoscanate | 100 | 20 | 100 | 28 | 34 | 100 |
| Carbachol | 89 | ND, topical application | ||||
| Chlorambucil | 95 | ND, toxic | ||||
| Chlorcyclizine HCl | 78 | 77 | 78 | 23 | 30 | 31 |
| Chlorhexidine dihydrochloride | 61 | ND, topical application | ||||
| Chloroxylenol | 100 | ND, topical application | ||||
| Chlorpromazine | 100 | ND, toxic | ||||
| Chlorprothixene HCl | 100 | ND, toxic | ||||
| Chlorpyrifos | 97 | ND, toxic | ||||
| Cisplatin | 87 | ND, toxic | ||||
| Clemastine fumarate | 76 | 91 | 2 | 47 | 30 | 100 |
| Clomiphene citrate | 80 | ND, toxic | ||||
| Coumophos | 100 | ND, toxic | ||||
| Cyproheptadine HCl | 88 | ND, toxic | ||||
| Dexlansoprazole | 88 | 35 | 1 | 47 | 17 | 55 |
| Diatrizoic acid | 81 | ND, toxic | ||||
| Dibenzothiophene | 100 | ND, topical application | ||||
| Dicyclomine HCl | 71 | 88 | 7 | 42 | 100 | 93 |
| Dimpylate | 100 | ND, toxic | ||||
| Doramectin | 100 | ND, anthelmintic | ||||
| Doxepin HCl | 64 | ND, toxic | ||||
| Drofenine HCl | 62 | 87 | 100 | 44 | 20 | 100 |
| Dyclonine HCl | 100 | ND, topical | ||||
| Eprinomectin | 100 | ND, anthelmintic | ||||
| Ethopropazine HCl | 100 | 89 | 100 | 33 | 100 | 100 |
| Fenbendazole | 66 | ND, anthelmintic | ||||
| Fenthion | 97 | ND, toxic | ||||
| Ftaxilide | 73 | ND, commercially not available | ||||
| Hexachlorophene | 100 | ND, topical | ||||
| Histamine dihydrochloride | 62 | ND, topical | ||||
| Mebendazole | 78 | ND, anthelmintic | ||||
| Metformin HCl | 100 | 11 | 100 | 50 | 27 | 75 |
| Metitepine mesylate | 70 | ND, toxic | ||||
| Morantel citrate | 60 | 100 | 100 | 47 | 80 | 94 |
| Moxidectin | 100 | ND, anthelmintic | ||||
| Natamycin | 95 | 14 | 100 | 53 | 10 | 61 |
| Phenothiazine | 98 | ND, toxic | ||||
| Phenylmercuric acetate | 100 | ND, topical | ||||
| Pramoxine HCl | 100 | ND, topical | ||||
| Pyrantel pamoate | 91 | ND, anthelmintic | ||||
| Selamectin | 79 | ND, anthelmintic, topical | ||||
| Tetramizole HCl | 100 | ND, anthelmintic | ||||
| Thiabendazole | 93 | ND, anthelmintic | ||||
| Thonzonium bromide | 98 | ND, topical | ||||
| Trichlorfon | 100 | 89 | 100 | 100 | 79 | 100 |
| Triclosan | 98 | ND, topical | ||||
| Triflupromazine HCl | 83 | ND, toxic | ||||
| Trimeprazine tartrate | 64 | ND, toxic | ||||
| Trimipramine maleate | 62 | 79 | 99 | 7 | 23 | 75 |
| Zoxazolamine | 98 | ND, toxic | ||||
Abbreviation: ND Not done