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. Author manuscript; available in PMC: 2017 Apr 5.
Published in final edited form as: Int Rev Neurobiol. 2016 Apr 5;127:181–210. doi: 10.1016/bs.irn.2016.03.001

Fig. 1. Modulating Hsp70 with KU-596 decreased the expression of txnip in diabetic DRG in an Hsp70-dependent manner.

Fig. 1

Wild type (A) and Hsp70 KO (B) mice were rendered diabetic with streptozotocin and after 12 weeks of diabetes, treated with vehicle or weekly doses of KU-596 at 20 mg/kg for 4 weeks. mRNA was harvested from the lumbar DRG and used for RNA-Seq analysis. Shown are representative alignments to the mouse txnip gene from non-diabetic, diabetic and diabetic animals that received KU-596 therapy. Dark blue bars indicate sequences that mapped to the forward strand while dark red bars are sequences that mapped to the reverse strand of the 8 exons of the txnip gene. See Ma et al., (2015) for additional details.