Table 1.
Characteristics of Subjects
| Patients Without Diabetes (NDM) |
Patients With Diabetes (DM) |
Total | |||||
|---|---|---|---|---|---|---|---|
| Total | Lean | Obese | Total | Lean | Obese | ||
| n (male/female) | 50 (26/24) | 40 (17/23) | 10 (9/1) | 49 (35/14) | 40 (28/12) | 9 (7/2) | 99 (61/38) |
| Age, y | 64 ± 14 | 64 ± 14 | 63 ± 13 | 67 ± 9 | 67 ± 8 | 67 ± 13 | 65 ± 12 |
| BMI, kg/m2 | 22.5 ± 2.7 | 21.5 ± 1.9 | 26.4 ± 1.2a | 21.9 ± 3.5 | 20.7 ± 2.4 | 27.6 ± 1.6a | 22.2 ± 3.1 |
| HbA1c, %c | 5.6 ± 0.5 | 5.7 ± 0.5 | 5.6 ± 0.6 | 7.8 ± 1.6b | 7.8 ± 1.8b | 7.5 ± 0.9b | 6.7 ± 1.6 |
| HbA1c, mmol/molc | 38 ± 6 | 38 ± 6 | 37 ± 6 | 61 ± 18b | 62 ± 19b | 58 ± 10b | 50 ± 18 |
| GA, %d | 14.8 ± 1.8 | 14.8 ± 1.8 | N/A | 21.2 ± 4.4b | 21.6 ± 4.9b | 20.1 ± 2.7b | 20.1 ± 4.7 |
| PG, mmol/Le | 6.24 ± 1.20 | 6.21 ± 1.21 | 6.37 ± 1.23 | 8.33 ± 2.52b | 8.44 ± 2.71b | 7.83 ± 1.41b | 7.27 ± 2.22 |
| CPR, nmol/Le,f | 0.57 (0.37–0.96) | 0.56 (0.36–0.69) | 1.03g | 0.51 (0.34–0.71) | 0.54 (0.31–0.71) | 0.50 (0.39–0.80) | 0.56 (0.36–0.73) |
| CPR index, (nmol/L)/ (mmol/L)f | 0.101 (0.060–0.155) | 0.085 (0.058–0.115) | 0.174g | 0.063 (0.045–0.086) | 0.056 (0.044–0.085) | 0.066 (0.055–0.102) | 0.065 (0.047–0.103) |
| Duration of DM, y | — | — | — | 8 ± 9 | 7 ± 9 | 9 ± 6 | — |
| Medication for diabetes, n, % | |||||||
| Diet only | — | — | — | 14 (28) | 13 (33) | 1 (11) | — |
| OHA | — | — | — | 20 (41) | 13 (33) | 7 (78) | — |
| Insulin ± OHA | — | — | — | 15 (31) | 14 (35) | 1 (11) | — |
| Clinical diagnosis, n, % | |||||||
| Neuroendocrine tumor | 13 (26) | 10 (25) | 3 (30) | 7 (14) | 7 (18) | 0 (0) | 20 (20) |
| Pancreatic cancer | 28 (56) | 24 (60) | 4 (40) | 34 (70) | 28 (70) | 6 (67) | 62 (63) |
| IPMN | 9 (18) | 6 (15) | 3 (30) | 7 (14) | 5 (12) | 2 (22) | 16 (17) |
| Othersh | 0 (0) | 0 (0) | 0 (0) | 1 (2) | 0 (0) | 1 (11) | 1 (1) |
| Operative procedure, n, % | |||||||
| Distal pancreatectomy | 40 (80) | 31 (78) | 9 (90) | 33 (68) | 29 (73) | 4 (44) | 73 (74) |
| Pancreatoduodenectomy | 6 (12) | 6 (15) | 0 (0) | 12 (24) | 7 (17) | 5 (56) | 18 (18) |
| Total pancreatectomy | 4 (8) | 3 (7) | 1 (10) | 4 (8) | 4 (10) | 0 (0) | 8 (8) |
Abbreviations: IPMN, intraductal papillary mucinous neoplasm; N/A, not available; OHA, oral hypoglycemic agent. Data with normal distribution are expressed as mean ± SD, and nonnormally distributed data are expressed as median (interquartile range).
a
P < .05 vs lean.
b
P < .05 vs NDM.
c
HbA1c was obtained in 93 subjects.
d
GA was obtained in 35 subjects.
e
Timing of blood sampling (ie, fasting or postprandial) was not determined.
f
CPR and CPR index were obtained in 56 subjects.
g
n = 2. CPR index was calculated as CPR (nanomoles per liter)/PG (millimoles per liter).
h
Disseminated sarcoma originating from small intestine.