Table 2.

Ion channels investigated.

Ion Channels		Effects and numbers of rapid estrogen actions					Referencesb
Type	Subtype	↑a	↓	--	others	Total
K+	BK	35	12	2	1	50	[3, 7, 16, 17, 24, 29, 32, 36-56] // [1, 13, 44, 57-62] // [63, 64] // [65].
	Kdr (or Kr)	1	13	1	0	15	[19, 35, 66-76].
	KATP	7	8	0	0	15	[28, 77-89].
	Kir	1	10	2	0	13	[66, 71, 73, 74, 90-97].
	KA	0	7	3	0	10	[63, 68, 73, 74, 76, 91, 98-100]
	GIRK	0	6	0	0	6	[101-105]
	Kv	0	2	2	0	4	[9, 32, 35]
	hERG	0	4	0	0	4	[106-109]
	KCNQ1	0	4	0	0	4	[107, 108, 110, 111]
	Misc	6	6	2	0	14	[6, 57, 58, 91, 97, 112-118].
	Total	50	72	12	1	135
Ca2+	Ca-L	7	28	2	0	37	[12, 21, 34, 119-122]/[6, 14, 22, 63, 66, 123-141]/[51, 88].
	T-type	0	4	1	0	5	[6, 141, 142] // [22]
	N-type	1	2	0	0	3	[143] // [22, 126].
	Cav	1	8	0	0	9	[5, 61, 84, 144-149].
	[Ca++]i	11	6	1	0	18	[10, 11, 18, 30, 33, 86, 114, 150-153] // [15, 28, 148, 154-156] // [157]
	Ca2+ influx	6	3	0	0	9	[23, 158-162] // [26, 163, 164].
	Misc	4	6	0	0	10	[2, 84, 165-168] // [72, 169, 170].
	Total	30	57	4	0	91
Na+	All	2	10	0	0	12	[75, 171] // [31, 66, 68, 73, 97, 107, 108, 172, 173].
Cl-	All	2	5	1	0	8	[174, 175] // [66, 111, 176-178] // [66].
Ligand-gated	KAR	3	0	1	0	4	[8, 179-181].
	nAChR	1	4	0	0	5	[4, 182-184].
	NMDAR	4	0	2	0	6	[8, 25, 144, 185-187].
	5-HT3R	0	2	0	0	2	[172, 182]
	AMPAR	1	0	0	0	1	[181]
	P2X3	0	2	0	0	2	[188, 189].
	GABAAR	0	1	0	2	3	[190, 191]
	Total	9	9	3	2	23

^asymbols: ↑, denote increase, activation; ↓, reduction, inhibition, blockade; --, no significant effect; others, undefined modulation.

^bReferences for different effects are presented in order in different clusters separated by //.