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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Steroids. 2016 Mar 3;111:46–53. doi: 10.1016/j.steroids.2016.02.018

Table 3.

Analyses of the conflicting results from BK and Ca-L.

Ion channel Estrogen action Cases n= Estrogens Signaing path Tissue/cell used (n, %) Ref's
Agent Dose
BK ↑ 35 E2: n=18;
E2=Tmx, n=2;
E2=PhytoE, n=2;
phytoE, n=3;
BPA, n=2;
Tmx, n=7;
G-1, ICI 182,780, estrone, DPN, PPT, n=1 each;
E2=E-BSA: n=2;
Tmx=imperm, n=2;
BPA=BPA-Ms, n=1;		 100 nM to 100 mM cGMP, n=5;
cAMP/PKA, n=1		 Muscle (23, 66%);
Neuron (1, 3%);
HEK-293 (3,8%);
MCF-7 (2, 6%);
Others (6, 17%).		 [3, 7, 16, 17, 24, 29, 32, 36-56].
↓ 12 E2, n=7;
E2 metab, n=2;
ICI 182,780, n=1;
Tmx, n=2;
E2=E-BSA, n=1;
Tmx=imperm,n=2;		 100 pM to 30 mM PKA/PKC, n=1 Muscle (3, 25%);
Neuron (4, 33%);
HEK-293 (2, 17%);
Endothelial cells (3, 25%).		 [1, 13, 57-62, 192].
Ca-L ↑ 7 E2, n=5;
E-BSA, XE, n=1, each;
E2=E-BSA, n=1;
E2=E-peroxidase, n=1.		 1 pM to 100 nM cAMP/PKC, n=1. Muscle, n=2 (29%);
Neuron, n=1 (14%); Others, n=4 (57%).		 [12, 21, 34, 119-122]
↓ 27 E2, n=19;
EB, EE2, DES, XE, phytoE, ICI 172,780, n=1, each;
SERM, n=2;
E2=E-BSA, n=2;
E2=DES=EE2, n=2;
E2=ICI 172,780, n=1.		 1-100 mM * PLC-MAPK-CREB, n=1;
G-protein, n=1.		 Muscle (16, 59%);
Neuron (9, 33%);
Others (2, 8%).		 [6, 14, 22, 63, 66, 123-137, 139-141].
*

except for one study that used 1-100 pM.