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Evolutionary analysis of mutation region. The missense mutation in ABCB7 and deletion in ATP7A genes change the amino-acid sequences that are highly conserved in vertebrates. Level of evolutionarily amino acid conservation illustrated by shading from white for non-conserved to dark gray for highly conserved. Alignments were obtained from the UCSC Genome Browser (Multiz Alignments of 100 Vertebrates),48 ClustalW.49
