Table 3: ADMSCs effect on acute renal injury, regenerative and chronicity scores in the outer stripe of the outer medulla of rat kidney after cisplatin (n = 5 in each group for each time subgroup; mean ± SD).
Control | Cispl. | Cispl.+ C.Medium | Cispl.+ ADMSC | |
---|---|---|---|---|
Necrotic tub. | ||||
4 | 0.0±0.0 | 12.6±2.1* | 8.4±1.7* | 3.9±0.3*° |
7 | 0.0±0.0 | 8.6±1.3*‡ | 8.3±1.5* | 4.6±0.4*° |
11 | 0.0±0.0 | 7.4±1.8*‡ | 7.5±2.2* | 2.6±0.2*°‡† |
30 | 0.0±0.0 | 4.7±0.1*‡†• | 2.4±0.3*‡†• | 1.0±0.6*°‡†• |
Inflam. cells | ||||
4 | 0.0±0.0 | 8.8±1.3* | 8.4±1.6* | 1.8±0.2*° |
7 | 0.0±0.0) | 8.4±1.6* | 8.3±1.9* | 1.5±0.3*° |
11 | 0.0±0.0 | 8.5±1.1* | 8.1±1.5* | 0.0±0.0°‡† |
30 | 0.0±0.0 | 4.7±0.2*‡†• | 4.4±0.3*‡†• | 0.0±0.0°‡† |
Reg. Tub. | ||||
4 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 1.2±0.2*° |
7 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 2.7±0.2*°‡ |
11 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 7.5±1.6*°‡† |
30 | 0.0±0.0 | 1.4±0.2*‡†• | 1.6±0.3*‡†• | 7.4±2.9*°‡† |
Mitosis | ||||
4 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 2.2±0.8*° |
7 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 3.7±0.2*°‡ |
11 | 0.0±0.0) | 1.7±0.2*‡† | 1.5±0.3*‡† | 4.5±0.3*°‡† |
30 | 0.0±0.0 | 1.7±0.2*‡† | 1.5±0.2*‡† | 4.9±0.9*°‡† |
Solid Sheets | ||||
4 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 2.8±0.8*° |
7 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 4.8±0.6*°‡ |
11 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 5.7±0.5*°‡ |
30 | 0.0±0.0 | 1.3±0.2*‡†• | 1.4±0.4*‡†• | 6.9±2.8*°‡ |
Int. Fibrosis | ||||
4 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 | 0.0±0.0 |
7 | 0.0±0.0) | 23.7±0.91*‡ | 23.1±1.4*‡ | 4.6±0.3*°‡ |
11 | 0.0±0.0 | 34.2±1.3*‡† | 32.8±2.3*‡† | 11.9±1.8*‡°† |
30 | 0.0±0.0) | 47.6±2.6*‡†• | 43.7±2.7*‡†• | 17.8±1.7*°‡†• |
Atrophic Tub. | ||||
4 | 0.0±0.0 | 13.3±2.3* | 12.5±1.4* | 6.5±0.3*° |
7 | 0.0±0.0 | 12.7±1.2* | 12.5±1.3* | 4.7±0.4*°‡ |
11 | 0.0±0.0 | 12.4±0.8* | 12.3±0.6* | 3.8±1.8*°‡ |
30 | 0.0±0.0 | 4.4±0.2*‡†• | 4.6±0.2*‡†• | 2.8±0.6*°‡† |
Significant difference compared to corresponding * control, ° cisplatin groups
Significant difference compared to intragroup day4‡, day7†, day11• Kruskal-Wallis test at P≤0.05