Table 4.

Best overall response

	Phase 1				Phase 2	Phase 1-2
	45 mg/m2 (n = 3)	56 mg/m2 (n = 3)	70 mg/m2 (n = 15)	88 mg/m2 (n = 6)	70 mg/m2 (n = 89)	70 mg/m2 (n = 104)
Stringent CR, n (%)	0	1 (33)	1 (7)	1 (17)	2 (2)	3 (3)
CR, n (%)	0	2 (67)	4 (27)	1 (17)	7 (8)	11 (11)
Very good PR, n (%)	0	0	3 (20)	0	31 (35)	34 (33)
PR, n (%)	1 (33)	0	6 (40)	2 (33)	26 (29)	32 (31)
Minimal response, n (%)	1 (33)	0	1 (7)	1 (17)	6 (7)	7 (7)
Stable disease, n (%)	1 (33)	0	0	0	12 (13)	12 (12)
Progressive disease, n (%)	0	0	0	0	2 (2)	2 (2)
Not evaluable, n (%)	0	0	0	1 (17)	3 (3)	3 (3)
ORR, % (95% CI)	33	100	93	67	74	77 (68-85)
CBR, % (95% CI)	67	100	100	83	81	84 (75-90)