Table 5.

PK parameters following a 30-minute IV infusion of carfilzomib

Parameter*	Dose
	20 mg/m2 (n = 25)	70 mg/m2 (n = 21)	88 mg/m2 (n = 5)
t1/2, h	0.64 (0.193-1.29)	0.950 (0.572-1.29)†	0.848 (0.648-0.952)‡
Cmax, ng/mL	724 (42.9)	2390 (30.7)	3090 (27.3)
AUC0-last, ng × h/mL	260 (27.6)	1030 (20.5)	1190 (29.1)
AUCinf, ng × h/mL	260 (27.6)	1030 (21.2)§	1140 (31.5)‡
CL, L/h	146 (30.4)	131 (28.6)§	138 (34.3)‡

AUC_0-last, AUC from time 0 to last time measurable concentration; AUC_inf, AUC from time 0 to infinity; CL, clearance; t_1/2, terminal half-life.

^*Except for t_1/2, which is expressed as median (minimum to maximum), all other parameters are shown as geometric mean (% coefficient of variation).

^†n = 16.

^‡n = 4.

^§n = 17.