Figure 4.
Interactions of the H2A.Z L1 loop residues with the H2A L1 loop and DNA in the heterotypic H2A.Z/H2A nucleosome. (a) Interaction between the H2A.Z Ser42 and H2A Glu41 residues in the heterotypic H2A.Z/H2A nucleosome. The dotted line indicates a possible hydrogen bond with a 2.6 Å length. The H2A.Z and H2A molecules are coloured pink and blue, respectively. (b) Interaction between H2A.Z His43 and a backbone phosphate of the DNA. The dotted line indicates a possible hydrogen bond with a 3.3 Å length. The H2A.Z and DNA molecules are coloured pink and bright green, respectively. (c) The B-factors for each Cα atom of H2A.Z in the heterotypic H2A.Z/H2A nucleosome (black circles). As a reference, the B-factors for each Cα atom of H2A.Z in the homotypic H2A.Z nucleosome (grey circles, PDB ID: 3WA9) are also plotted. The secondary structure of H2A.Z in the nucleosomes is shown at the top of the panel.
