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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Neuropharmacology. 2015 Feb 3;93:116–123. doi: 10.1016/j.neuropharm.2015.01.018

Fig. 2. Effect of Knockdown of GR in the CeA.

Fig. 2

A) The number of abdominal contractions in response to graded colonic distension was similar in the CHOL VEH and CHOL GR RSO groups. GR ASO in the CHOL-implanted rats induced a significant increase in colonic sensitivity to isobaric distension at all pressures tested. The response to colonic distension was similarly increased in the CORT-implanted rats treated with VEH. B) Somatic withdrawal threshold in CHOL-implanted rats treated with VEH was not affected by GR RSO administration. In contrast, GR ASO infusions in CHOL-implanted rats induced a significant decrease in withdrawal threshold that mirrored the decrease in the CORT VEH group. Data is represented as mean ± SEM, n=6/group. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. CHOL VEH, †† p < 0.01 vs. CORT VEH, one- or two-factor ANOVA with- or with-out repeated measures, Tukey Post-hoc test.