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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Neuropharmacology. 2015 Feb 3;93:116–123. doi: 10.1016/j.neuropharm.2015.01.018

Fig. 3. Effect of Knockdown of MR in the CeA.

Fig. 3

A) Both the CHOL VEH and CHOL MR RSO groups had similar responses to colonic distension. MR ASO in the CeA induced a significant visceral hyperalgesia to colonic distension in rats with CHOL-implants, partially reproducing the visceral hypersensitivity induced by the CORT-implant on the CeA. B) MR RSO infusions in the CeA of CHOL-implanted rats did not change somatic sensitivity as compared to the CHOL VEH group. However, MR ASO also failed to change somatic withdrawal threshold, whereas there was a significant decrease demonstrated in the CORT VEH group. Data is represented as mean ± SEM, n=6/group. * p < 0.05, ** p < 0.01 vs. CHOL VEH, † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. CORT VEH, one- or two-factor ANOVA with- or with-out repeated measures, Tukey Post-hoc test.