Figure 7. MyBP‐C phospho‐ablation alters the timing of the cardiac cycle after β‐adrenergic stimulation .

A, in WT and TnI^PKA− mice, dobutamine administration shortens the relative duration of IVC, ejection and IVR, and lengthens the relative duration of diastolic filling, whereas MyBPC^PKA‐ and DBL^PKA− mice displayed an increased relative duration of ejection time, a decreased relative duration of filling time and an unchanged IVC duration after dobutamine. The relative duration of IVR was increased by dobutamine in DBL^PKA− mice but unchanged in MyBPC^PKA− mice. All durations were normalized to the total length of the cardiac cycle and are presented as the percentage change from baseline values. B, dobutamine administration significantly shortened the relative duration of systole and prolonged the relative duration of diastole in WT and TnI^PKA− mice compared to baseline, whereas systole was relatively prolonged and diastole relatively shortened in MyBPC^PKA‐ and DBL^PKA− mice after dobutamine. All durations were normalized to the total length of the cardiac cycle and all values are presented as a percentage of baseline. *Significantly different from WT values (P < 0.05).