Table 2.
Left ventricular haemodynamic function measured by P–V loop analysis
| Group | P max (mmHg) | EDP (mmHg) | PFR (μl s−1) | PER (μl s−1) | HR (beats min–1) | dp/dtmax (mmHg s−1) | τ (ms) |
|---|---|---|---|---|---|---|---|
| Baseline | |||||||
| WT | 95.3 ± 5.2 | 5.0 ± 0.7 | 13.0 ± 1.5 | 12.8 ± 1.2 | 452 ± 12 | 7,134 ± 570 | 6.4 ± 0.1 |
| TnIPKA− | 102.5 ± 3.4 | 9.6 ± 1.0 | 10.6 ± 0.6 | 8.7 ± 1.0 | 430 ± 13 | 7,082 ± 627 | 6.8 ± 0.3 |
| MyBPCPKA− | 94.0 ± 5.8 | 6.6 ± 1.0 | 11.7 ± 1.0 | 11.9 ± 1.9 | 450 ± 9 | 7,618 ± 585 | 6.8 ± 0.3 |
| DBLPKA− | 88.3 ± 3.3 | 10.7 ± 2.1† | 13.0 ± 0.8 | 11.2 ± 1.6 | 427 ± 7 | 7,599 ± 798 | 6.6 ± 0.2 |
| + Dobutamine | |||||||
| WT | 98.1 ± 4.7 | 4.4 ± 0.6 | 24.9 ± 1.2* | 32.8 ± 1.8* | 541 ± 9* | 13,756 ± 967* | 4.9 ± 0.2* |
| TnIPKA− | 108.4 ± 4.7 | 6.4 ± 0.7* | 21.1 ± 1.2* | 27.9 ± 1.6* | 579 ± 14* | 14,879 ± 947* | 4.7 ± 0.2* |
| MyBPCPKA− | 88.21 ± 5.7 | 4.3 ± 0.5* | 14.9 ± 1.5† | 14.4 ± 1.6† | 529 ± 9* | 8,437 ± 791† | 6.2 ± 0.3† |
| DBLPKA− | 81.6 ± 4.2 | 4.6 ± 0.6* | 18.1 ± 1.5* † | 17.1 ± 1.9* † | 528 ± 15* | 9,130 ± 942† | 6.1 ± 0.3† |
Values are the mean ± SEM from seven to 10 mice per group. *Significantly different from the corresponding baseline group (without dobutamine treatment) (P < 0.05). †Significantly different from WT (P < 0.05).