Table 3.
In vivo assessment of blood pressure using implantable telemetry
| Group | Systolic pressure (mmHg) | Diastolic pressure (mmHg) | Time to peak (ms) | HR (beats min–1) |
|---|---|---|---|---|
| Baseline | ||||
| WT | 127.0 ± 11.0 | 110.6 ± 12.3 | 27 ± 2 | 675 ± 19 |
| TnIPKA− | 126.6 ± 3.8 | 96.0 ± 5.7 | 28 ± 3 | 658 ± 15 |
| MyBPCPKA− | 128.7 ± 9.7 | 106.7 ± 11.5 | 28 ± 4 | 624 ± 42 |
| DBLPKA− | 126.9 ± 6.8 | 106.1 ± 6.1 | 28 ± 2 | 604 ± 27 |
| + Dobutamine | ||||
| WT | 99.6 ± 3.3* | 74.1 ± 3.6* | 19 ± 1* | 757 ± 8* |
| TnIPKA− | 98.4 ± 2.0* | 71.9 ± 3.6* | 20 ± 1* | 823 ± 34* |
| MyBPCPKA− | 78.1 ± 4.1*, † | 63.1 ± 6.6* | 26 ± 2† | 690 ± 38* |
| DBLPKA− | 81.9 ± 3.6*, † | 67.3 ± 2.6* | 24 ± 1† | 737 ± 22* |
Values are expressed as the mean ± SEM from four or five mice per group. *Significantly different from the corresponding baseline group (without dobutamine treatment) (P < 0.05). †Significantly different from WT (P < 0.05).