Table 2. Significant results of the analysis of APCS, RBP4 and AR SNPs and AO variation taking into account intrafamilial nonindependency.
| Gene | SNP | Genotypes | B | 95% CI | P-value |
|---|---|---|---|---|---|
| APCS | GG (reference) | − | − | − | |
| rs28383573 | TTa | 26.17 | (23.08; 29.25) | P<0.001 | |
| RBP4 | CC (reference) | − | − | − | |
| rs7094671 | TT | 18.95 | (4.10; 33.80) | 0.012 | |
| CT | 10.42 | (2.38; 18.46) | 0.011 | ||
| rs11187545 | TT (reference) | − | − | − | |
| CCa | −28.49 | (−44.56; −12.42) | 0.001 | ||
| CT | −8.98 | (−17.06; 16.67) | 0.035 | ||
| AR (male group) | T (reference) | − | − | − | |
| rs5919393 | C | −10.59 | (−19.14; −2.04) | 0.015 | |
| G (reference) | − | − | − | ||
| rs17217069 | A | −10.38 | (−14.22; −6.54) | P<0.001 | |
| A (reference) | − | − | − | ||
| rs2361634 | G | −8.88 | (−14.45; −3.31) | 0.002 | |
| AR (female group) | CC (reference) | − | − | − | |
| rs5919392 | CT | −8.53 | (−12.76; −4.30) | P<0.001 | |
| TT (reference) | − | − | − | ||
| rs5919393 | CT | 6.63 | (3.38; 9.87) | P<0.001 | |
| AA (reference) | − | − | − | ||
| rs2361634 | GA | −6.96 | (−11.00; −2.92) | 0.001 | |
| AA (reference) | − | − | − | ||
| rs5965433 | AT | −6.76 | (−12.97; −0.56) | 0.033 |
B, unstandardized coefficient (estimated quantitative effect of each genotype on AO variation compared with the reference genotype); CI, confidence interval; P-value, significance level was set to 0.05.
a
Based in only one individual with this genotype.