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MMP interventions that worsen post-MI outcomes
| Intervention | Model | Time post-MI effect observed | Effect |
|---|---|---|---|
| RXP 470.1 (MMP-12i)19 | Mouse | Days 1–7 | ↑ LV dilation, ↑ inflammation |
| MT1-MMP Tg18,46 | Mouse | Up to 14 days | ↑ LV remodeling, fbrosis, ↓ survival |
| MMP-28 null20 | Mouse | Up to 28 days | ↑ LV dysfunction and rupture |
Abbreviations: ↓, decreased; ↑, increased; MMP, matrix metalloproteinase; MI, myocardial infarction; Lv, left ventricle; MT, membrane type; Tg, transgenic.
