Table 1. Significantly increased translation factors and ribosomal proteins in SZ hiPSC NPCs observed by SILAC quantitative mass spectroscopy.
| SILAC | Gene family | Protein names | Up | Down | Global up | Global down |
|---|---|---|---|---|---|---|
| P1A × C1 | 2289 | 752 | ||||
| Translation initiation factor | Up: EIF2AK2, EIF2AK4, EIF2B1, EIF2B2, EIF2B3, EIF2S2, EIF3S3, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF3S10, EIF3S12, EIF4A2, EIF4A3, EIF4AB, EIF4G1, EIF4G2, EIF4G3, EIF5, EIF5A, EIF5B | 38 | 0 | |||
| Down: | ||||||
| Ribosomal protein | Up: RPL3, RPL4, RPL6, RPL7, RPL8, RPL9, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL21, RPL22L1, RPL23, RPL23A, RPL24, RPL27A, RPL32, RPL36A, RPL37A, RPL38, RPLP0, RPLP1, RPLP2, RPN, RPN2, RPS2, RPS3, RPS6, RPS7, RPS10, RPS11, RPS12, RPS13, RPS17, RPS19, RPS20, RPS21, RPS24, RPS25, RPS27 | 66 | 0 | |||
| Down: | ||||||
| P1B × C1 | 2401 | 886 | ||||
| Translation initiation factor | Up: EIF2AK2, EIF2AK4, EIF2B1, EIF2B2, EIF2B3, EIF2S2, EIF2S3, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S8, EIF3S9, EIF3S10, EIF3S12, EIF4A2, EIF4A3, EIF4B, EIF4G1, EIF4G2, EIF4G3, EIF5, EIF5A, EIF5B | 36 | 0 | |||
| Down: | ||||||
| Translation elongation factor | Up: EEF1A1, EEF1A2, EEF1B2, EEF1E1, EEF1G, EEF2Down: | 7 | 0 | |||
| Ribosomal protein | Up: RPL3, RPL4, RPL6, RPL7, RPL7A, RPL8, RPL9, RPL10A, RPL14, RPL15, RPL17, RPL18, RPL18A, RPL21, RPL22L1, RPL23, RPL26, RPL26L1, RPL27A, RPL32, RPL36A, RPL37A, RPL38, RPLP0 RPLP1, RPLP2, RPLP10, RPS2, RPS3, RPS6, RPS7, RPS10, RPS12, RPS13, RPS17, RPS19, RPS20, RPS21, RPS24, RPS25, RPS27 | 48 | 1 | |||
| Down: RPL22 | ||||||
| P3 × C3 | 1123 | 366 | ||||
| Translation initiation factor | Up: EIF2B1, EIF2S2, EIF2S3,EIF3S2, EIF3S4, EIF3S5, EIF3S12, EIF4A3, EIF4E, EIF5, EIF5A | 10 | 4 | |||
| Down: EIF2C1, EIF2C3, EIF2C12 | ||||||
| Translation elongation factor | Up: EEF1A1, EEF1A2, EEF1GDown: | 3 | 0 | |||
| Ribosomal protein | Up: RPL3, RPL8, RPL9, RPL10A, RPL14, RPL15, RPL17, RPL23, RPL32, RPLP1, RPLP2, RPS2, RPS7, RPS17 | 14 | 1 | |||
| Down: RPL22L1 | ||||||
| P3 × C6 | 541 | 880 | ||||
| Translation initiation factor | Up: EIF3S5, EIF4G1, EIF5A | 3 | 4 | |||
| Down: EIF2A, EIF2C1, EIF2C3,ELAV | ||||||
| Ribosomal protein | Up: RPA3, RPL21, RPL23A, RPL23AP2, RPL8, RPLP2, RPS3A, RPS29 | 10 | 3 | |||
| Down: RPL11, RPL36, RPS12, | ||||||
| Total | 235 | 13 | 6354 | 2884 |
Abbreviations: hiPSC, human-induced pluripotent stem cell; NPC, neural progenitor cell; SILAC, stable isotope labeling by amino acids in cell culture; SZ, schizophrenia.