Table 2. Significantly increased translation factors and ribosomal proteins in SZ hiPSC NPCs observed by label-free LC–MS/MS quantitative mass spectroscopy.
| Gene family | Protein names | Up | Down | Global up | Global down |
|---|---|---|---|---|---|
| 194 | 108 | ||||
| Translation initiation factor | Up: EIF1, EIF2S3, EIF3A, EIF3C, EIF3F, EIF4A, EIF4A3, EIF5A, EIF6 | 9 | 0 | ||
| Down: | |||||
| Translation elongation factor | Up: EEF1A1, EEF2 | 2 | 0 | ||
| Down: | |||||
| Ribosomal protein | Up: RPL3, RPL7, RPL7A, RPL10, RPL10A, RPL12, RPL21, RPL22, RPL23, RPL27,RPL30, RPL36, RPLP0, RPLP2, RPS3, RPS8, RPS11,RPS12, RPS17L, RPS25, RPS26, RPSA | 22 | 1 | ||
| Down: PRPS1 | |||||
| Total | 33 | 1 | 194 | 108 |
Abbreviations: hiPSC, human-induced pluripotent stem cell; LC–MS/MS, liquid chromatography–mass spectrometry/MS; NPC, neural progenitor cell; SZ, schizophrenia.