Table 3. Discriminative values of serum p75NTR-ECD using an ROC curve analysis.
| ROC analysis | AD versus EC | AD versus PD | AD versus stroke | AD versus non-AD |
|---|---|---|---|---|
| AUC | 0.752 | 0.689 | 0.702 | 0.720 |
| P-value | <0.001 | <0.001 | <0.001 | <0.001 |
| 95% CI | 0.695–0.808 | 0.623–0.754 | 0.633–0.771 | 0.666–0.774 |
| Cutoff, pg ml−1 | 34.2 | 48.6 | 35.8 | 41.5 |
| Sensitivity, % | 70.5 | 48.7 | 65.4 | 63.4 |
| Specificity, % | 74.4 | 93.7 | 81.9 | 76.3 |
| Accuracy, % | 72.5 | 75.3 | 73.7 | 69.9 |
Abbreviations: AD, Alzheimer's disease; AUC, area under the ROC; 95% CI, 95% confidence interval; EC, elderly control without neurologic disorders; PD, Parkinson disease; p75NTR-ECD, ectodomain of p75 neurotrophin receptor; ROC, receiver operating characteristic.