Table 1. Results of an experimental approach to find the best threshold of magnitude (|ALR|) and probability (P) of differentially expressed transcripts between MK801-treated and control animals.
|ALR| | P | EXP | Boot 1 | Boot 2 | Boot 3 | FDR (%) |
---|---|---|---|---|---|---|
0.585 | 0.05 | 74 | 39 | 12 | 14 | 34.5 |
0.848 | 0.05 | 24 | 15 | 5 | 3 | 41.7 |
0.585 | 0.01 | 15 | 11 | 4 | 2 | 50.0 |
0.848 | 0.01 | 3 | 3 | 1 | 0 | 66.7 |
0.263 | 0.005 | 46 | 25 | 12 | 5 | 40.2 |
0.585 | 0.005 | 4 | 3 | 1 | 2 | 50.0 |
0.848 | 0.005 | 1 | 0 | 0 | 0 | 0.0 |
Abbreviations: |ALR|, absolute average log2 ratio; Boot 1–3, number of probes surpassing the same criteria in permutation comparisons; EXP, number of probes meeting the |ALR| and P criteria for difference in expression between MK801- and control animals; FDR, false discovery rate.