Table 1. SNPs associated with cocaine dependence in the NFAT5 gene in a Spanish sample of 806 cocaine-dependent patients and 817 controls.
|
Controls N (%) |
Cases N (%) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus | Marker | Predicted effect | 11 | 12 | 22 | Sum | 11 | 12 | 22 | Sum | P-valuea | Adj P-valueb | OR (95% CI) | |
| NFAT5 | rs1437134 | G>A | miRNA binding | 278 (34.2) | 384 (47.3) | 150 (18.5) | 812 | 325 (40.5) | 370 (46.1) | 108 (13.4) | 803 | 0.00118c | 0.00031c | 1.27 (1.10–1.45)d |
| rs7359336 | A>G | miRNA binding | 278 (34.1) | 386 (47.3) | 152 (18.6) | 816 | 321 (40.2) | 369 (46.2) | 109 (13.6) | 799 | 0.00141c | 0.00035c | 1.25 (1.09–1.45)d | |
| rs11641233 | C>T | miRNA binding | 516 (63.2) | 264 (32.3) | 37 (4.5) | 817 | 461 (57.5) | 286 (35.7) | 55 (6.8) | 802 | 0.00734 | 0.02599 | 1.25 (1.06–1.47) | |
| rs6499244 | A>T | miRNA binding | 264 (32.4) | 390 (47.8) | 161 (19.8) | 815 | 293 (36.5) | 385 (48.0) | 124 (15.5) | 802 | 0.0156 | 0.00474 | 1.37 (1.03–1.37)d | |
| rs12232410 | G>A | miRNA binding | 516 (63.3) | 262 (32.2) | 37 (4.5) | 815 | 463 (57.5) | 288 (35.8) | 54 (6.7) | 805 | 0.00749 | 0.0351 | 1.25 (1.06–1.47) | |
Abbreviations: CI, confidence interval; miRNA, microRNA; OR, odds ratio; SNP, single-nucleotide polymorphism.
a
Log-additive model.
b
Adjusted by age.
c
Survive Bonferroni correction P<0.0022.
d
When OR<1, the inverted score is shown.