Table 1. Effects of 4-week antipsychotic treatment and add-on mifepristone treatment on serum lipid and hormone parameters.

Experiments	Serum parametersa	Treatment groups (n=7, each)
		NC	SER	HAL	ARI	RISb	CLOb
Antipsychotic treatment	Triacylglycerols	0.79±0.38	0.69±0.20	0.61±0.14	0.78±0.19	1.22±0.18*	1.21±0.30*
	Total cholesterol	1.50±0.32	1.57±0.30	1.53±0.36	1.82±0.33	2.07±0.52*	2.55±0.84**
	Free fatty acids	0.74±0.14	0.73±0.12	0.88±0.20	1.01±0.28	2.41±0.55***	2.94±0.85***
	Progesterone	44.02±28.89	124.58±11.04	80.11±48.81	65.37±25.95	221.97±81.53**	312.63±16.92***
	Corticosterone	0.54 ±0.26	0.12±0.11	0.82±0.40	0.88±0.29	3.14±1.15***	1.76±0.49**
	Insulin	36.66±12.14	39.24±11.88	38.24±11.82	32.01±11.24	40.96±8.46	42.96±12.13
		NC	MIF	CLOb	CLO+MIFc	RISb	RIS+MIFc
Add-on MIF treatment	Triacylglycerols	0.55±0.33	0.41±0.15	1.86±0.56**	0.29±0.10+++	1.46±0.35**	0.29±0.07+++
	Total cholesterol	1.60±0.33	1.27±0.26	2.67±0.70**	1.34±0.26++	2.12±0.57*	1.03±0.25+++
	Free fatty acids	1.68±0.55	1.33±0.15	3.09±0.87*	1.31±0.48+++	2.62±0.54*	1.33±0.39++
	Progesterone	49.75±15.42	69.76±18.13	283.08±20.55**	234.18±84.23	139.71±73.97**	139.58±67.83
	Corticosterone	0.48±0.23	0.52±0.17	2.67±0.22***	2.13±1.21	1.82±0.47**	1.63±0.97
	Insulin	28.68±4.44	22.85±4.19	28.42±5.91	22.90±7.08	30.48±8.39	23.32±6.73

Abbreviations: ARI, aripiprazole; CLO, clozapine; HAL, haloperidol; MIF, mifepristone; NC, normal control; RIS, risperidone; SER, sertraline.

*P<0.05, **P<0.01 and ***P<0.0001 (for antipsychotic effects); ⁺⁺P<0.01 and ⁺⁺⁺P<0.0001 (for add-on MIF treatment effects).

^aSerum triacylglycerol, total cholesterol and free fatty acid were expressed as mmol l⁻¹, whereas progesterone, corticosterone and insulin were expressed as nmol l⁻¹, μmol l⁻¹ and mIU l⁻¹, respectively.

^bSignificant differences were conducted between treatment-alone and NC groups.

^cSignificant differences were conducted between treatment-alone and add-on MIF treatment groups.