3. Study definitions of resolution of infection.

Study	Study definitions of resolution of infection
Klastersky 1983	Improved ‐ Lasting return of temperature, signs and symptoms to normal or to pre‐infectious state.	Temporarily improved ‐ As for "Improved" but with relapse in 3‐6 days despite continuing antibiotic therapy.
Price 2015	Participant had to meet two criteria: 1. survival for 42 days after randomisation 2. clinical response of the study‐qualifying infection assessed at 42 days. bloodstream infections was defined as a negative blood culture invasive bacterial or fungal infections, was defined as resolution or improvement of clinical evidence of infection by clinical, laboratory and radiographic parameters. Assessment of response was by a blinded adjudication panel.
Scali 1978	Not further defined
Vogler 1977	Complete resolution of infectious episode: all evidence of infection must clear within the 21‐day period. Measurable parameters included resolution of fever, conversion of cultures to negative and healing of involved sites.	Partial resolution: less than complete clearing but definite clinical improvement in more than one measurable parameter for the 21‐day period.
Winston 1982a	Resolution of septicaemia ‐ afebrile, antimicrobials have been stopped, and follow‐up blood cultures were negative Resolution of pneumonia ‐ afebrile, clinical and radiological improvement, and antimicrobials have been stopped Resolution of cellulitis or an abscess ‐ afebrile, no remaining localising signs of an infection, and antimicrobials have been stopped