Comparison 3. Sub group analyses for studies published before and after the year 2000.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall mortality (up to 30 days)	6		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Older studies (published before 2000)	5	210	Risk Ratio (M‐H, Fixed, 95% CI)	0.53 [0.33, 0.85]
1.2 Newer studies (published 2000 or later)	1	111	Risk Ratio (M‐H, Fixed, 95% CI)	1.10 [0.70, 1.73]
2 Clinical response and reversal of infection	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Older studies (published before 2000)	4	189	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.80, 1.21]
2.2 Newer studies (published 2000 or later)	1	97	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.61, 1.55]