Fig 2. High Doses of Resveratrol Reduce Cellular Proliferation.

N1 immortalized prostate (A), primary prostate (B) or Idiopathic Pulmonary Fibrosis (IPF) lung fibroblasts were cultured in SF media supplemented with vehicle or increasing doses of Resveratrol (10–200 μM) for 24 hours, then assessed using a WST assay. None of the cell lines tested proliferated in media supplemented with increasing doses of Resveratrol (light gray lines). N1 (A) and primary (B) prostate fibroblasts as well as IPF lung fibroblasts (C) proliferated in response to CXCL12 or TGFβ though this response was ablated in media supplemented with increasing concentrations of Resveratrol. In all cases, CXCL12 promoted a more robust proliferative response than TGFβ.