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. 2016 Jun 30;10:1947–1959. doi: 10.2147/DDDT.S101449

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© 2016 Ge et al. This work is published and licensed by Dove Medical Press Limited

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Effects of X22 on chemically-induced inflammation in vivo.

Notes: (A) Ear swelling induced by dimethyl benzene. (B) Acetic acid-induced writhing response. (C) Acetic acid-induced vascular permeability. Formalin-induced nociception mice, (D) first-inflammatory phase, 0–10 minutes after formalin induction, and (E) second-inflammatory phase, 15–30 minutes after formalin induction. Control animals received saline (0.9% NaCl). Each value represents the mean ± SEM of six mice, and asterisks indicate the significant difference of pretreated group and model group to the corresponding saline group (*P<0.05, **P<0.01, ***P<0.01 relative to the LPS group).

Abbreviations: LPS, lipopolysaccharide; OD value, optical density value; SEM, standard error of mean.