Skip to main content
. Author manuscript; available in PMC: 2017 Mar 29.
Published in final edited form as: Cell Rep. 2016 Mar 17;14(12):2901–2911. doi: 10.1016/j.celrep.2016.02.066

Fig. 2. Thioredoxin-1 protects Salmonella against the antimicrobial activity of the NADPH phagocyte oxidase.

Fig. 2

C57BL/6 (B6) and congenic gp91phox- or iNOS-deficient mice were challenged orally with ~3 × 106 CFU/mouse of wild-type (WT) or ΔtrxA Salmonella (A–C). The survival of Salmonella-infected mice was scored over time. According to log-rank, Mantel-Cox survival test, ΔtrxA Salmonella are attenuated (p < 0.001) in B6 and iNOS-deficient mice. The competitive index was measured in the livers of C57BL/6 and gp91phox-deficient mice 48 h after i.p. inoculation with 500 CFU of a mixture containing equal numbers of ΔtrxA::km and WT Salmonella (D). *, p < 0.5. Survival of Salmonella in periodate-elicited peritoneal macrophages (E). ***, p < 0.001. The data are the mean ± SD of 9 biological repeats done on 3 independent days.