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. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Methods Mol Biol. 2015;1253:35–45. doi: 10.1007/978-1-4939-2155-3_3

Table 1. Significant interactions affecting HDL-C levels validated in multiple population cohorts.

(Regenerated from Ref [6] )

Test Stage	Cohort	SNP 1				SNP 2				P _c ^c

		rsID	Chr	Pos^a	Gene^b	rsID	Chr	Pos^a	Gene^b
Discovery	ARIC EA	rs12916	5	74656539	HMGCR (3’ UTR)	rs1532085	15	58683366	40.8k U LIPC	0.008
Fine Mapping	ARIC EA	rs3846662	5	74651084	HMGCR (Intron)	rs2043085	15	58680954	43.2k U LIPC	0.002
Validation	MESA EA	rs3846662	5	74651084	HMGCR (Intron)	rs1973688	15	58582540	141.6k U LIPC	0.006
Validation	FHS EA	rs55727654	5	74651864	HMGCR (Intron)	rs473422	15	58666341	57.8k U LIPC	0.002
Validation	MESA HA	rs1423527	5	74602699	30.3k U HMGCR	rs7163280	15	58718340	5.8k U LIPC	0.04
Validation	ARIC AA	rs3761743	5	74685520	27.6k D HMGCR	rs567838	15	58736623	LIPC (Intron)	0.004

^a

Build 37.1 (GRCh37)

^b

U = upstream of; D = downstream of

^c

P-value after Bonferroni correction