Table 5.

Examples of anti-tumor compounds

Compound	Chemistry	Species/order	Mode of action	References
Isoaaptamine	Benzonaphthyridine alkaloid	Aaptos aaptos/Hadromerida	Protein kinase C inhibitor	Fedoreev et al., 1988
Debromohymenialdisine	Pyrrole-guanidine alkaloid, prenylhydroquinone derivative	Hymeniacidonaldis/Halichondrida	Protein kinase C inhibitor	Kitagawa et al., 1983
Adociasulfates	Triterpenoid hydroquinones	Sarcotragus sp./ Dictyoceratida Haliclona (aka Adocia) sp./Haplosclerida	A1, 3-fucosyltransferase inhibitor Kinesin motor protein inhibitors	Zapolska-Downar et al., 2001
Discodermolide	Linear tetraene lactone	Discodermia dissolute/ Lithistida	Stabilization of microtubules	Ter Haar et al., 1996
Peloruside A	Macrocyclic lactone	Mycdle hentschett/ Poecilosclerida	Stabilization of microtubules	Hood et al., 2002
Elenic acid	Alkylphenol	Plakinastrella sp./ Homosclerophorida	Topoisomerase II inhibitor	Hood et al., 2002
Naamine D	Imidazole alkaloid	Leucetta cf. chagosensis	Nitric oxide synthetase inhibitor	Juagdan et al., 1995
Agelasphin (KRN7000)	a-Galactosylceramide	Agelas mauritianus / Agelasida	NKT cell activator	Shimosaka, 2002
Crambescidins 1–4	Pentacyclic guanidine derivative	Crambe crambe/Poecilosclerida	Ca2+/channel blocker	Jares-Erijman et al., 1991
Discorhabdin D	Fused pyrrolophenanthroline alkaloid	Latrunculia brevis/Poecilosclerida; Prianos sp./Haplosclerida	Unknown	Perry et al., 1990
Glaciasterols A and B	9, 11-Secosterol	Aplysilla glacialis/Dendroceratida	Unknown	Pika et al., 1992
Durumolides A–C	Terpenoid	Lobophytum duru	Inducible NOS and COX-2 inhibition	Cheng et al., 2008
Plakortide P	Polyketide	Plakortis angulospiculatus	TXB2 inhibition	Kossuga et al., 2008
24-methoxypetrosaspongia C	Sesterterpenes	Hyrtios erectus	Unknown	Elhady et al., 2016