Figure 4.

Results on day 5 after daily oral doses of dexlansoprazole 60 mg given 30 minutes before meals or an evening snack. (A) Mean linear plasma concentration–time profiles and (B) mean intragastric pH measurements. On the 24-hour scale, the x-axis shows hour 8:00 on the morning of day 5 to hour 8:00 on day 6. Upward and downward pointing arrows indicate the beginning and end of the monitoring periods for each regimen, respectively. For the lunch, dinner and snack regimens, data after 8:00 hours on day 6 are transposed to the beginning of the chart so that the mean 24-hour pH profiles of all 4 regimens can be compared in a single 24-hour view that reflects the diurnal effect of treatment on pH. Reprinted from Lee et al⁴² with permission from John Wiley & Sons, Inc. ©2010 Takeda Global Research & Development Center, Inc.