Table 1.

Identified functions of mammalian Sestrin isoforms.

Functions	Inhibits ROS in cells	In vitro a Ahp activity	Binds to Keap1	Inhibits mTORC1 in cells	Binds to GATOR2	Binds to mTORC2	Activates Akt in cells	Activates AMPK in cells	In vitro leucine binding
Sesn1	O	-	O	O	O	-	O	O	O
Sesn2	O	O	O	O	O	O	O	O	O
Sesn3	O	-	-	O	O	O	O	O	▲
Ref	[7,27]	[21]	[13]	[8,62]	[17–19]	[15]	[11,15]	[8,62]	[23]

^aalkylhydroperoxidase

O = Functional

▲ = Weak

- = Undetermined