Table 5.

Global Significance of SSRI Exposure on Major White Matter Pathways in Neonates.

Tract	N	N	FA	MD	RD	AD
Tract	Case	Control	FA	MD	RD	AD
Corticofugal
Left Prefrontal	20	40	0.294	< 0.001	0.002	0.017
Right Prefrontal	20	40	0.156	< 0.001	0.004	0.065
Left Premotor	20	40	0.422	0.007	0.013	0.072
Right Premotor	20	40	0.164	< 0.001	0.002	0.181
Left Motor	20	40	0.48	0.009	0.025	0.048
Right Motor	20	40	0.534	0.002	0.018	0.021
Left Parietal	20	40	0.389	0.004	0.014	0.071
Right Parietal	20	40	0.501	0.022	0.038	0.227
Corticothalamic
Left Prefrontal	20	40	0.123	0.002	0.014	0.005
Right Prefrontal	20	40	0.435	0.014	0.027	0.1
Left Premotor	20	40	0.369	0.004	0.003	0.096
Right Premotor	20	40	0.093	< 0.001	< 0.001	0.024
Left Motor	20	40	0.122	0.004	0.004	0.023
Right Motor	20	40	0.412	0.027	0.052	0.035
Left Parietal	20	40	0.072	0.006	0.005	0.078
Right Parietal	20	40	0.417	0.023	0.051	0.066
Medial Lemniscus
Left	20	40	0.0697	0.257	0.468	0.347
Right	19	38	0.447	0.227	0.362	0.159
Optic Tract
Left	20	38	0.211	0.008	0.034	0.01
Right	20	38	0.873	< 0.001	< 0.001	0.011
Corpus Callosum
Orbitofrontal	20	40	0.046	0.058	0.035	0.137
Prefrontal	20	40	0.285	0.157	0.171	0.119
Premotor	20	40	0.495	0.465	0.531	0.222
Motor	20	40	0.511	0.418	0.409	0.25
Parietal	20	40	0.855	0.328	0.382	0.296
Occipital	20	40	0.902	0.516	0.63	0.429
Temporal	20	40	0.069	0.11	0.137	0.068
Arcuate fasciculus
Left Frontoparietal	18	39	0.952	0.33	0.369	0.419
Left Frontotemporal	19	39	0.491	0.252	0.177	0.399
Right Frontoparietal	15	36	0.73	0.402	0.567	0.219
Right Frontotemporal	19	40	0.489	0.356	0.288	0.661
Right Temporoparietal	17	40	0.776	0.119	0.159	0.139
Cingulum
Left Cingulate Gyrus	19	40	0.029	0.134	0.056	0.475
Right Cingulate Gyrus	18	37	0.359	0.009	0.028	0.046
Right Hippocampal	12	39	0.512	0.077	0.059	0.36
Fornix
Left	20	40	0.529	0.151	0.242	0.067
Right	19	37	0.349	0.424	0.389	0.37
Inferior Fronto-occipital fasciculus (IFOF)
Left	20	40	0.397	0.055	0.085	0.056
Right	20	40	0.933	0.032	0.048	0.06
Inferior Longitudinal Fasciculus (ILF)
Left	20	40	0.969	0.611	0.595	0.65
Right	20	40	0.163	0.366	0.272	0.39
Superior longitudinal fasciculus (SLF)
Left	14	38	0.733	0.868	0.885	0.69
Right	12	36	0.033	0.136	0.05	0.452
Uncinate Fasciculus
Left	20	40	0.076	0.024	0.017	0.045
Right	20	40	0.1	0.012	0.021	0.056

Bold/italicized text indicates p-values below 0.05 (unadjusted for multiple comparisons), gray shading indicates p-values surviving Bonferroni correction (0.05/45 = 0.001)