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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Am J Psychiatry. 2016 Feb 19;173(7):695–704. doi: 10.1176/appi.ajp.2015.15040414

Figure 4.

Figure 4

Predicted probability of new-onset bipolar spectrum for risk profiles defined by significant predictors in the overall probit model. Predicted risk differed substantially between someone with no symptoms (baseline anxiety/depression, proximal affective lability, and proximal manic symptoms all 1 S.D. below the mean) vs. someone with all of these symptoms (1 S.D. above the mean). Predicted risk also differed according to parental age of mood disorder onset, looking in particular at an individual 1 S.D. below the mean (parent proband developed mood disorder at 11 years old) vs. 1 S.D. above the mean (parent proband developed mood disorder at 29 years old). Results are adjusted for age at proximal visit, a nuisance covariate in this analysis.