Table 2.
Impact of individual baseline factors on the hazard of developing bipolar spectrum (and bipolar-I/II) over follow-up, adjusting for demographics, parental non-bipolar categorical disorders, and offspring non-bipolar categorical disorders. Hazard ratios associated with a one standard-deviation increase in each factor are given.
| Bipolar Spectrum (n=44) | Bipolar I/II (n=15) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| X2 | Hazard Ratio | 95% CI | p | X2 | Hazard Ratio | 95% CI | P | ||
|
| |||||||||
| Parent Reports |
Internalizinga | 18.70 | 1.78 | 1.37, 2.31 | <0.0001b | 11.85 | 2.07 | 1.37, 3.12 | 0.0006b |
| Externalizing | 4.11 | 1.41 | 1.01, 1.95 | 0.04 | 3.91 | 1.69 | 1.00, 2.84 | 0.05 | |
| Inattention/Disinhibition | 2.36 | 1.16 | 0.96, 1.41 | 0.1 | 1.26 | 1.16 | 0.90, 1.51 | 0.3 | |
|
| |||||||||
| Child Reports |
Internalizing | 8.81 | 1.54 | 1.16, 2.06 | 0.003b | 3.15 | 1.60 | 0.95, 2.69 | 0.08 |
| Externalizing | 8.54 | 1.78 | 1.21, 2.63 | 0.004b | 4.62 | 2.07 | 1.07, 4.01 | 0.03 | |
| Affective Labilitya | 13.58 | 1.66 | 1.27, 2.18 | 0.0002b | 13.97 | 2.24 | 1.47, 3.42 | 0.0002b | |
|
| |||||||||
| Depression Rating Scale |
Depressive/Atypical Symptoms | 1.95 | 1.24 | 0.92, 1.67 | 0.2 | 0.13 | 1.09 | 0.68, 1.77 | 0.7 |
| Sleep Problems | 0.03 | 0.98 | 0.75, 1.28 | 0.9 | 0.02 | 0.97 | 0.64, 1.48 | 0.9 | |
| Suicidality | 5.70 | 1.23 | 1.04, 1.47 | 0.02b | 1.86 | 1.22 | 0.92, 1.62 | 0.2 | |
|
| |||||||||
| Mania Rating Scale | Total Score | 2.03 | 1.21 | 0.93, 1.58 | 0.2 | 0.53 | 1.19 | 0.75, 1.90 | 0.5 |
a
Significant in the penalized (Lasso) Cox Regression Model
b
Significant after correcting for multiple comparisons (False Discovery Rate)