Table 3.
Impact of individual proximal factors on the hazard of developing bipolar spectrum (and bipolar-I/II) over follow-up, adjusting for demographics, parental non-bipolar categorical disorders, and offspring non-bipolar categorical disorders. Odds ratios associated with a one standard-deviation increase in each factor are given.
| Bipolar Spectrum (n=44) | Bipolar I/II (n=15) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| X2 | Odds Ratio | 95% CI | p | X2 | Odds Ratio | 95% CI | p | ||
|
| |||||||||
| Parent Reports |
Internalizing | 11.15 | 1.76 | 1.26, 2.45 | 0.0008b | 3.18 | 1.57 | 0.96, 2.57 | 0.07 |
| Externalizing | 13.80 | 1.91 | 1.36, 2.68 | 0.0002b | 2.72 | 1.55 | 0.92, 2.60 | 0.1 | |
| Inattention/Disinhibition | 8.81 | 1.67 | 1.19, 2.35 | 0.003b | 2.65 | 1.55 | 0.91, 2.62 | 0.1 | |
|
| |||||||||
| Child Reports |
Internalizing | 6.54 | 1.65 | 1.12, 2.41 | 0.01b | 2.90 | 1.76 | 0.92, 3.35 | 0.09 |
| Externalizing | 7.52 | 1.76 | 1.18, 2.65 | 0.006b | 0.002 | 1.02 | 0.53, 1.97 | 0.96 | |
| Affective Labilitya | 12.78 | 1.82 | 1.31, 2.52 | 0.0004b | 7.80 | 2.09 | 1.25, 3.51 | 0.005 b | |
|
| |||||||||
| Depression Rating Scale |
Depressive/Atypical Symptoms | 2.78 | 1.29 | 0.96, 1.73 | 0.1 | 0.01 | 0.97 | 0.56, 1.68 | 0.9 |
| Sleep Problems | 5.06 | 1.40 | 1.04, 1.88 | 0.02b | 1.10 | 1.28 | 0.81, 2.02 | 0.3 | |
| Suicidality | 3.57 | 1.30 | 0.99, 1.71 | 0.06 | 3.38 | 1.37 | 0.98, 1.91 | 0.07 | |
|
| |||||||||
| Mania Rating Scale | Total Scorea | 21.73 | 2.14 | 1.55, 2.94 | <0.0001b | 4.01 | 1.48 | 1.01, 2.17 | 0.05 |
a
Significant in the penalized (Lasso) Logistic Regression Model
b
Significant after correcting for multiple comparisons (False Discovery Rate)