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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Alcohol Clin Exp Res. 2016 May 24;40(7):1443–1453. doi: 10.1111/acer.13104

Table 3.

Results from the meta-analysis under an A9-dominant model for alcohol dependence stratified by different datasets

Datasets of meta-analysis (A9/A9+A9/A* vs. A*/A*) Cohorts (n) Sample size (N) Estimate of heterogeneity Fixed-effects model Random-effects model Egger (j)
I2 (%) PQ Pooled OR 95% CI PZ Pooled OR 95% CI PZ PE
Data based on all ethnic population(a) 22 5,929 32.8 0.07 1.12 1.00–1.25 0.045** 1.12 0.97–1.30 0.13 0.74
Data based on Caucasian population(b) 12 4,027 41.9 0.06 1.15 1.01–1.31 0.036** 1.17 0.97–1.41 0.097 0.45
Data based on Asian population(c) 8 993 15.2 0.31 1.06 0.77–1.45 0.73 1.06 0.74–1.52 0.74 0.33
Data based on other population(d) 2 909 71.6 0.06 1.04 0.79–1.37 0.79 0.94 0.53–1.69 0.84 NA
Data based on DSM-IV(e) 10 3,457 39.0 0.10 1.18 1.03–1.36 0.02** 1.21 1.00–1.47 0.05** 0.28
Data based DSM-III-R(f) 8 1,082 22.9 0.25 0.91 0.67–1.23 0.54 0.93 0.64–1.35 0.70 0.66
Data based ICD-10(g) 3 1,345 56.6 0.10 1.12 0.89–1.40 0.35 1.11 0.76–1.60 0.59 0.93
Data based on alcoholic subgroups(h) 6 1,591 37.9 0.15 1.55 1.24–1.92 1.0×10−4** 1.55 1.16–2.06 0.0028** 0.996
Data based on alcoholic subgroups(i) 5 1,411 0.0 0.70 1.71 1.36–2.16 1.0×10−5** 1.71 1.36–2.16 1.0×10−5** 0.34

Note:

**

Statistically significant value. 95% CI indicates the 95% confidence interval. NA: Not Applicable.

(a)

Analysis of the data combined all ethnic population from included studies.

(b)

Analysis of the data only based on Caucasian population.

(c)

Analysis of the data only based on Asian population.

(d)

Analysis of the data only based on Brazilian and Mexican population.

(e)

Analysis of the data that the criteria of the alcohol dependence syndrome according to DSM-IV.

(f)

Analysis of the data that the criteria of the alcohol dependence syndrome according to DSM-III-R.

(g)

Analysis of the data that the criteria of the alcohol dependence syndrome according to ICD-10.

(h)

Analysis of the data that contain the subgroups of alcoholics with withdrawal seizure or delirium tremens and controls.

(i)

Analysis of the data that contain the subgroups of alcoholics with withdrawal seizure or delirium tremens and controls (excluded the study of Le Strat et al., 2008)

(j)

Egger regression test for publication bias.