Table 2.
Summary of results and Cohen’s d effect sizes.
| Task | Outcome | Manipulation Check* | GLM Results
|
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|---|---|---|---|---|---|---|---|---|---|
| Main Effects | Interactions | ||||||||
|
|
|
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| Med | Bev | Time | Med x Time | Bev x Time | M x B x T | ||||
| Subjective Reactivity | Craving Subjective | F=6.24, p=.02 | F=5.15, p=.03c,d | ||||||
| Intoxication | F=15.27, p<.01 | F=3.38, p=.04b | |||||||
|
| |||||||||
| Cognitive Function | CPT | Omissions | F=3.51, p=.08 | F=4.64, p=.04c | F=2.94, p=.07b | ||||
| Commissions | F=5.51, p=.03 | F=4.74, p=.02c | |||||||
| DSST | Attempts | F=3.40, p=.04b,d | |||||||
| Successes | F=3.14, p=.06b,d | ||||||||
| N-back 1 | Correct | F=4.34, p=.06 | F=3.29, p=.05b | ||||||
| Total Time | F=7.46, p=.02 | F=3.33, p=.05c,d | |||||||
|
| |||||||||
| Perceptual Motor Function | Pursuit Rotor | Average % on Target | F=10.07, p<.01 | F=2.50, p=.1b,d | |||||
|
| |||||||||
| Physiologic Reactivity | Systolic BP | F=3.62, p=.08 | F=5.77, p=.02c | ||||||
| Diastolic BP | F=5.48, p=.03 | F=4.26, p=.02c,d | |||||||
| Heart Rate | F=19.82, p<.01 | F=3.36, p=.05b | F=16, p<.01c | F=2.64, p=.08b | |||||
Note: Blank cells are n.s.
No significant medication by beverage interactions.
*
Manipulation Check for main effect of beverage or beverage by time in placebo only subjects. Cohen d Effect size:
a
Small (0.1 – 0.3),
b
medium (0.4 – 0.6),
c
large (0.7 - >0.9)
d
Controlled for baseline (−45 timepoint; for outcomes with baseline differences only).