Table 1.
Patient characteristics
| Simvastatin | Placebo | |
|---|---|---|
|
| ||
| N | 13 | 12 |
|
| ||
| Age | 59 ± 12 | 60 ± 10 |
|
| ||
| Gender – Female % | 62% | 67% |
|
| ||
| Race – Caucasian % | 86% | 92% |
|
| ||
| Smoker (%) | 38% | 50% |
|
| ||
| Hypertension (%) | 23% | 50% |
|
| ||
| Coronary artery disease (%) | 0 | 8% |
|
| ||
| *HDL cholesterol (mean ± SD) | 57 ± 18.3 | 63 ± 19.8 |
|
| ||
| *LDL cholesterol (mean ± SD) | 115 ± 51.9 | 81 ± 26.8 |
|
| ||
| *Anti-platelet therapy (%) | 0 | 8% |
|
| ||
| Heavy alcohol use (%) | 7% | 8% |
|
| ||
| Admitted on SAH day (%) | Day of hemorrhage – 10 | Day of hemorrhage – 9 |
| 1 day post bleed - 3 | 1 day post bleed - 2 | |
| 2 days post bleed - 1 | ||
|
| ||
| * Mean blood pressure (mean ± SD) | 107 ± 11.9 | 102 ± 23.2 |
|
| ||
| Intubated (%) | 7% | 16% |
|
| ||
| *WFNS Grade(N) | 2 – 4 | 2 – 2 |
| 3 – 6 | 3 – 3 | |
| 4 – 1 | 4 – 5 | |
| 5 – 2 | 5 – 2 | |
|
| ||
| *Modified Fisher Scale (N) | 1 – 0 | 1 – 1 |
| 2 – 2 | 2 – 2 | |
| 3 – 7 | 3 – 6 | |
| 4 – 4 | 4 – 3 | |
|
| ||
| *Intraventricular hemorrhage(%) | 46% | 67% |
|
| ||
| Moderate/severe angiographic vasospasm (%) | 42% | 45% |
|
| ||
| Delayed cerebral ischemia with rescue therapy (%) | 14% | 55% |
|
| ||
| Modified Rankin Scale (6-month) | N | N |
| 0 | 3 | 0 |
| 1 | 3 | 2 |
| 2 | 4 | 4 |
| 3 | 0 | 4 |
| 4 | 0 | 2 |
| 5 | 1 | 0 |
| 6 | 2 | 0 |
*
On admission