Table 3.

Number of prostate cancers (NC), HRs and 95% CIs for HR for prostate cancer incidence in diabetic compared with non-diabetic men according to 1st, 2nd and the rest of the follow-up years from diabetes diagnosis

Gleason score category	Follow-up: 2002–2012a HR (95% CI) 14,099 prostate cancer events including those in non-diabetics					Follow-up: 2005–2012a PSA-adjustedb HR (95% CI) 10,335 prostate cancer events including those in non-diabetics
	Incident diabetes n=193,835				Prevalent diabetes n=74,756	Incident diabetes n=185,888				Prevalent diabetes n=65,001
	1st year	2nd year	3rd year+	First 10 years		1st year	2nd year	3rd year+	First 7 years
All:
NC	767	354	1, 592		1, 672	460	276	1, 547		1, 113
HR	1.65	0.93	0.89	0.97	0.80	1.48	0.94	0.89	0.98	0.77
(95% CI)	(1.55, 1.76)	(0.84, 1.03)	(0.84, 0.95)	(0.93, 1.02)	(0.76, 0.85)	(1.37, 1.61)	(0.83, 1.06)	(0.84, 0.94)	(0.94, 1.02)	(0.72, 0.82)
2–6:
NC	420	217	961		885	271	179	940		637
HR	1.47	0.89	0.83	0.90	0.71	1.32	0.90	0.82	0.91	0.68
(95% CI)	(1.35, 1.60)	(0.77, 1.01)	(0.77, 0.89)	(0.85, 0.95)	(0.66, 0.76)	(1.19, 1.47)	(0.78, 1.05)	(0.77, 0.89)	(0.85, 0.96)	(0.62, 0.74)
7–10:
NC	180	66	377		358	119	51	369		269
HR	2.09	0.86	0.99	1.08	0.92	2.05	0.88	1.00	1.13	0.93
(95% CI)	(1.83, 2.38)	(0.66, 1.10)	(0.88, 1.11)	(0.98, 1.20)	(0.82, 1.03)	(1.75, 2.39)	(0.67, 1.17)	(0.89, 1.13)	(1.02, 1.25)	(0.82, 1.06)
Unknown:
NC	167	71	254		429	70	46	238		207
HR	1.78	1.18	1.09	1.17	0.98	1.51	1.21	1.08	1.16	0.96
(95% CI)	(1.56, 2.03)	(0.94, 1.48)	(0.94, 1.26)	(1.03, 1.31)	(0.88, 1.09)	(1.23, 1.86)	(0.92, 1.61)	(0.93, 1.25)	(1.01, 1.30)	(0.82, 1.12)

^aAdjusted for age category (5 year increments), SES and ethnic origin

^bAdjusted for PSA screening during 2002–2003

NC, number of cases