Table 1.

Genes encoding anti-angiogenic molecules expressed in first and third trimester trophoblast (signal > 200) as determined by microarray analysis

Gene symbol	Gene name	FTB	TTB
ANGPT2	Angiopoietin 2	735	a
ARRB1	Arrestin beta 1	336	446
CD59	CD59 complement fragment	713	724
COL4A1	Collagen type IV alpha 1	9985	2830
COL4A2	Collagen type IV alpha 2	7011	2570
COL4A3	Collagen type IV alpha 3/tumstatin	a	a
COL18A1	Collagen type XVIII alpha 1	a	a
CXCL2	Gro-beta	307	377
CXCL10	Chemokine ligand 10	227	a
FN1	Fibronectin	1165	681
FBLN5	Fibulin5	a	a
HSPGBM	Heparan sulfate proteoglycan of basement membrane	744	a
IFNA1	Interferon alpha	a	a
IFNB1	Interferon beta	a	a
IFNG1	Interferon gamma	a	a
IL4	Interleukin-4	a	a
IL12A	Interleukin-12A	a	a
IL12B	Interleukin-12B	a	a
IL18	Interleukin-18	a	a
KISS1	Kisspeptin	1121	a
LECT1	Leukocyte cell-derived chemotaxin (chondromodulin)	a	a
NRP1	Neuropilin 1	a	a
PF4	Platelet factor 4	a	a
PLG	Plasminogen fragment	a	a
PRL	Prolactin	a	233
RNH	Placental ribonuclease inhibitor	1932	2377
SDC3	Syndecan 3	212	a
SERPINB5	Maspin	a	a
SERPINC1	Serpin peptidase inhibitor, clade C (anti-thrombin III)	a	a
SERPINE1	Plasminogen activator inhibitor/serine peptidase inhibitor	11,887	9413
SERPINF1	Pigment epithelium-derived factor (PEDF)	776	2914
SPARC	Secreted protein, acidic, cysteine rich	2458	555
SPP1	Osteopontin	228	323
TGFB1	Transforming growth factor beta	a	a
THBS1	Thrombospondin 1	a	a
THBS2	Thrombospondin 2	a	a
TIMP1	Metalloproteinase inhibitor 1	1226	292
TIMP2	Metalloproteinase inhibitor 2	2849	2711
TIMP3	Metalloproteinase inhibitor 3	11,176	7901
TIMP4	Metalloproteinase inhibitor 4	a	a
TNNI3	Troponin I	a	a
TNFSF15	Tumor necrosis factor ligand superfamily, member 15/VEGI	a	a

a absent