Table 2.
Genes encoding anti-angiogenic proteins differentially expressed between first or third trimester trophoblast (signal > 200, fold change >2 or <−2) as determined by microarray analysis
| Gene symbol | Gene name | Fold change |
|---|---|---|
| SERPINF1/PEDF | Pigment epithelium-derived factor | −3.8 |
| THBS1 | Thrombospondin 1 | 2.6 |
| TIMP1 | Tissue inhibitor of metalloproteinases 1 | 4.2 |
| SPARC | Secreted protein, acidic, cysteine rich | 10.2 |
| SDC3 | Syndecan 3 | 11.8 |
| TGFB1 | Transforming growth factor beta 1 | 16.8 |
| ANGPT2 | Angiopoietin 2 | 17.5 |
| KISS1 | Kisspeptin | 101.9 |
Positive fold change indicates higher expression in first trimester trophoblast, while a negative fold change indicates higher expression in third trimester trophoblast
a absent