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| Intrinsec |
| RAC1 mutations |
| Stromal secretion HFG/cMET |
| Aberration CDK4, cyclin D1 |
| HOXD8 mutation |
| Acquired |
| Splicing BRAF |
| Copy gain or amplification BRAF |
| Upregulation TK receptors |
| ERK feedback |
| Intrinsec/acquired |
| MITF |
| Aberrations of PI3K/AKT pathway |
| Loss PTEN |
| Mutations MEK |
| COT expresión |
| Loss of NF1 |
| NRAF mutations |
CDK4, cyclin-dependent kinase 4; HFG, hepatocyte growth factor; MITF, microphthalmia-associated transcription factor.
